Requisite(s): 91707 Pharmacology 1
This subject develops and extends the principles governing drug and xenobiotic action covered in the prerequisite subject. Objectives are to further develop the concept of receptors as cellular determinants of drug and xenobiotic action and to develop the concepts of modulated receptors and ion channels in determining anaesthetic drug action. The clinical efficacy of the major pharmacology drug classes used in the treatment of diabetes and respiratory and musculoskeletal systems disorders. Endogenous opioids in pain control mechanisms and the interaction of opioid analgesics with these systems. Selective toxicity in the treatment of microbial, viral and protozoal infections. Toxicokinetic factors, defence mechanisms, cellular reactivity, receptors and binding sites as determinants of target organ toxicity. Drugs in the conception and birthing process. Carcinogens and teratogens. Specific classes of toxic substances. Lectures are complemented by a tutorial/practical program which emphasises the clinical nature of the subject and develops lecture material using a variety of experimental tutorial, computer simulation and case-study approaches.
Spring semester, City campus