91709 Pharmacology 2

Description

This subject develops and extends the principles governing drug and xenobiotic action covered in 91707 Pharmacology 1. It is designed to foster a problem-solving approach to pharmacology with particular emphasis on applying molecular pharmacology concepts to pathophysiological problems. The objectives are to further develop the concept of receptors as cellular determinants of drug and xenobiotic action, and to develop the concepts of modulated receptors and ion channels in determining drug action. Selective toxicity in the treatment of microbial, viral and protozoal infections is examined as well as toxicokinetic factors, defense mechanisms, cellular reactivity, receptors and binding sites as determinants of target organ toxicity. The clinical efficacy of the major pharmacology drug classes used in the treatment of cancer, affective and psychotic illnesses, cardiovascular disease, lipid disorders, blood disorders, diabetes, peptic ulcers, nausea and vomiting, and disorders of the respiratory and musculoskeletal systems, are examined. In addition, the abuse of drugs is examined including tobacco, alcohol, CNS stimulants, psychotomimetics and the mechanisms underlying drug dependence, including treatment of drug overdose and antidotal therapy in the context of clinical toxicology. Lectures are complemented by a tutorial program which emphasises the clinical nature of the subject and develops lecture material using a variety of tutorial and case study approaches.

Typical availability

Spring session, City campus